用于藥物輸送的納米顆粒技術(shù)
“市場上有許多珠(球)研磨機(jī)可供使用，從實(shí)驗(yàn)室規(guī)模到工業(yè)化生產(chǎn)規(guī)模的均有，產(chǎn)品能夠大規(guī)模生產(chǎn)是其進(jìn)入市場的一個(gè)必要條件，除了產(chǎn)品成本低，珠(球)研磨法的一個(gè)優(yōu)點(diǎn)就是能夠大規(guī)模生產(chǎn)?？紤]到簡便性的問題，研磨室通常設(shè)計(jì)成六角形，此時(shí)研磨室容積的76%都可以被研磨材料填充。1000L的研磨機(jī)對應(yīng)760L研磨材料：氧化鋯的表觀密度是3.96kg/L，需要2.8t的研磨材料。圖2.1給出了這個(gè)問題的解決方法。圖中示出的是Dispermat SL珠(球)研磨機(jī)和外部的混懸容器?；鞈乙和ㄟ^泵反復(fù)地通過珠(球)研磨機(jī)。這種方法減少了研磨材料的重量，但延長了研磨時(shí)間?！?/p>
Nanoparticle Technology for Drug Delivery
“There are a number of pearl mills available on the market, ranging from laboratory-scale to industrial-scale volumes. The ability for large-scale production is an essential prerequisite for the introduction of a product to the market.One advantage of the pearl mills, apart from being low-cost products, is their ability for scaling up. Assuming, for reasons of simplicity, hexagonal packaging of the milling pearls, 76% of the milling chamber volume will be filled by the pearls. In case of a 1000L mill this corresponds to 760L milling material; based on the apparent density of zircon oxide pearls being 3.69 kg/L, this corresponds to 2.8 tons of milling material.Figure 1 shows the solution for this problem, a pearl mill with an external suspension container. The suspension is continuously pumped through the pearl mill. This approach reduces the weight of the pearl mill itself, but it prolongs the milling times.”
